GLP-1 Supplements To Naturally Boost Your Metabolism

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Everyone is (still) talking about Ozempic. This infamous “weight loss” drug was first developed to help lower blood sugar levels for certain individuals with type 2 diabetes, but its weight loss effects have increasingly dominated the conversation. 

There are a few different medications on the market that work the same way Ozempic (semaglutide) does. These drugs are GLP-1 receptor agonists, which work by mimicking the effects of glucagon-like peptide-1 (GLP-1), a hormone that your body naturally produces when you eat. 

GLP-1 helps to increase insulin secretion and lower elevated blood sugar levels, and it sends signals to your brain to let it know that you’re full and can stop eating. It also helps to regulate appetite in general, keeping you full for longer. 

As a functional medicine expert, I’m not really a fan of these drugs for weight loss. They come with several possible side effects, including potential long term effects that we don’t even know about yet. 

And even if they work, they’re nothing more than a band-aid solution. They don’t address the underlying problems associated with weight loss resistance or a dysregulated metabolism. 

Which means that, not only do you usually have to keep taking these drugs for the rest of your life to keep the weight off, any hidden imbalances may go unaddressed and lead to further health issues. 

The good news is there are a few natural supplements that can help to boost GLP-1 production or mimic its metabolism-regulating effects. 

How Do GLP-1 Boosting Supplements Work?  

When compared to GLP-1 receptor agonist medications (like Ozempic), GLP-1 boosting supplements come with fewer side effects, are way less expensive, and generally offer additional health benefits. 

Most of the supplements we’ll talk about here help your body to naturally produce more GLP-1, through various different pathways. 

Some may also offer similar effects to GLP-1 receptor agonist drugs, including helping to balance blood sugar and supporting a healthy metabolism, appetite regulation, and fat loss, through different mechanisms. 

The weight loss effects of GLP-1 boosting supplements aren’t likely to be as dramatic or immediate as those of Ozempic. 

But if you’re interested in a more holistic, root-cause focused, sustainable approach to weight loss, combining strategic supplements with diet and lifestyle measures can make a meaningful difference. Let’s take a look at some of the best options.  

1. Yerba Mate

Yerba mate is a South American plant species that is often consumed as a tea, though it is also available as a supplement in other forms. Yerba mate has been shown to increase production of GLP-1, and to help reduce appetite and stimulate fat loss through both this and other mechanisms, making it a potentially helpful supplement for those with obesity or who are overweight. (1, 2)

Research has also shown that yerba mate may help to prevent type 2 diabetes and balance blood sugar. (3) Other benefits include antioxidant properties and anti-inflammatory effects. (4) Yerba mate also contains caffeine, and some people use it as an alternative to coffee to help boost energy in the morning or throughout the day. 

There are some potential risks associated with yerba mate if consumed in large amounts, especially at very hot temperatures, including the increased risk of certain kinds of cancer. (5)

2. Psyllium 

Psyllium is a great source of soluble fiber, which can help to naturally increase levels of GLP-1. (6) Psyllium is also thought to work in additional ways to help regulate appetite and prolong feelings of fullness, and to help stabilize blood sugar. (7, 8)

Psyllium and other fiber supplements are great for some people, and can be problematic for others. People with certain gastrointestinal conditions including Crohn’s disease should generally avoid psyllium. 

Especially if introduced too quickly or in high doses, psyllium can lead to digestive side effects including nausea, constipation, diarrhea, or cramping. If you do decide to take psyllium or other fiber supplements, make sure to drink lots of water to help prevent constipation. 

Long-term weight loss isn’t a quick fix, but there are ways to make it feel less impossible. The Metabolic Recharge identifies roadblocks hindering your progress to maintain weight loss for good. Join now. 

3. Ginseng 

Ginseng is an antioxidant-packed herb that has been used in traditional Chinese medicine for centuries to help support the immune system, manage blood sugar, support energy levels, and improve overall health. Research has shown that ginseng may help to boost GLP-1 release, and to improve blood sugar control for those with type 2 diabetes. (9, 10)

Ginseng may also help to regulate levels of leptin, another hormone that influences body weight and fat storage. (11)

Through these and other mechanisms, a growing body of research has found that ginseng can improve both obesity and metabolic syndrome. (12, 13)

4. Berberine 

Berberine is a natural plant compound that has been used in traditional and herbal medicine for thousands of years. 

Berberine is one of the most promising natural supplements available when it comes to weight loss, blood sugar control, and insulin sensitivity, leading many to start referring to it as “Nature’s Ozempic”. 

I should clarify that berberine, as a natural supplement, is not a 1:1 replacement for the injectable drug Ozempic. Berberine is not a magic pill to stimulate rapid weight loss, but an herbal compound that targets several root causes of weight gain and/or weight loss resistance, and supports overall metabolic, digestive, and immune health. 

Among other benefits, berberine has been shown to boost GLP-1, improve blood sugar, fight inflammation, improve cholesterol levels, and support heart and gut health. (14 - 19)

Berberine helps to regulate metabolism in part by activating an enzyme called AMPK, sometimes referred to as a “metabolic master switch”. (20) Activating this pathway helps promote the burning of fat, rather than glucose, for fuel, similar to what happens when you fast or follow a ketogenic diet. 

Through these and potentially other pathways, berberine can help to promote healthy weight loss and support an overall healthy metabolism. (21)

LISTEN: Hot Or Not: Berberine "Nature's Ozempic", Red Light Masks, Chia Seed Water, Taurine Supplements + Whole Body MRI Scans (Ask Me Anything Episode!)

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5. Curcumin 

Curcumin, a compound found in turmeric, has been shown to help promote secretion of GLP-1. (22) Research is still in its early stages, but a small human trial found that taking 1500 mg of curcumin daily helped to reduce weight and balance blood sugar levels for those with type 2 diabetes. (23) 

Curcumin may also help to reduce inflammation, increase antioxidant activity, improve pain for those with arthritis, and reduce risk of heart disease, among other benefits. 

Cooking or making warming drinks with turmeric is a great way to get some of the benefits of curcumin, and you can also take curcumin as a supplement for more of a boost. 

6. Bitter Melon

Bitter melon, a vine that produces a large green fruit similar to a cucumber, has been shown to help improve insulin resistance and blood sugar control for individuals with type 2 diabetes. This seems to be at least in part due to the fact that bitter melon stimulates the secretion of GLP-1. (24) 

Bitter melon may also help to reduce cholesterol levels, and it’s packed with important nutrients including vitamin C, vitamin A, and folate. 

While you can absolutely just add bitter melon to your diet (although it’s not always easy to find in North America), you may get more concentrated benefits by taking a supplement containing its extract. 

Precautions

All of the supplements I’ve mentioned here work differently, and while they’re all generally safe for most people, they also all have different possible side effects or, in some cases, interactions with certain medications. 

The most common side effects associated with most of these supplements are digestive, including constipation, diarrhea, or an upset stomach. Especially if you generally have a more sensitive digestive system, it’s a good idea to start slowly and keep an eye on how you feel. 

Supporting your gut with tools like probiotics, prebiotics, and an anti-inflammatory diet can also help to reduce any GI distress.

You may want to introduce only one new supplement at a time, and speak with a trusted functional medicine practitioner to help you determine which options and dosages may be right for you. 

Keep in mind that if you’ve been prescribed a glucagon-like peptide-1 receptor agonist like Ozempic for a medical condition like type 2 diabetes, supplements are not a replacement, and you should speak with your healthcare professional before making any changes.

READ MORE: Could This Be The Missing Ingredient In Your Healing? 

Finding The Right Supplement Plan For You

If you are looking for natural methods to support healthy weight loss or weight management, metabolism, and glucose control, supplements like berberine, curcumin, and psyllium that help to boost GLP-1 secretion are worth considering. 

It’s worth remembering that supplements can offer numerous benefits, but they’re not magic pills. These natural therapies work best when combined with dietary and lifestyle strategies to support your whole self, and when chosen thoughtfully. 

A qualified functional medicine practitioner can help you put together a plan that’s right for you, and that targets the underlying causes of your weight gain, weight loss resistance, or metabolic concerns.

As one of the first functional medicine telehealth clinics in the world, we provide webcam health consultations for people around the globe.

GLP-1 receptor agonists are a class of medication that mimic the natural intestinal hormone GLP-1, which plays an important role in appetite control and satiety, helping you to feel full for longer. They include Ozempic, Wegovy, and Mounjaro (different brand names for semaglutide and tirzepatide). 

Diet, exercise, and eating habits (including size and frequency of meals) can affect how much GLP-1 your body secretes. Some supplements can also influence GLP-1 levels.

You may be able to increase natural glp-1 secretion by making a few dietary changes. Certain foods, including healthy fats (especially omega-3 fatty acids) and high fiber foods, can help to increase GLP-1 levels naturally. Exercise has also been shown to help boost GLP-1 secretion. 

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BY DR. WILL COLE

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Dr. Will Cole, DNM, IFMCP, DC is a leading functional medicine expert who consults people around the globe, starting one of the first functional medicine telehealth centers in the world. Named one of the top 50 functional and integrative doctors in the nation, Dr. Will Cole provides a functional medicine approach for thyroid issues, autoimmune conditions, hormonal imbalances, digestive disorders, and brain problems. He is also the host of the popular The Art of Being Well podcast and the New York Times bestselling author of Intuitive Fasting, Ketotarian, Gut Feelings, and The Inflammation Spectrum.

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