Premenstrual Dysphoric Disorder (PMDD): What You Need To Know About This More Severe Form of PMS

Pmdd

For many women, premenstrual symptoms like bloating and cramping are things they have to deal with every month. However, for the 8% of women (1) who suffer from Premenstrual Dysphoric Disorder (PMDD) their symptoms go far beyond that of normal PMS and can become so debilitating they interfere with every aspect of their lives.

As a functional medicine practitioner, I see far too often the stigma that women face surrounding their menstrual cycle. Women can be made to feel like they are being overdramatic by both society and conventional medicine when in fact, there is a storm going on underneath the surface that isn’t getting the proper care.

Therefore, it is my job to shed light on PMDD, how it differs from regular PMS, ways to overcome this condition naturally, and bring awareness to the reality of this condition so that others can hopefully find validation and healing.

What is Premenstrual Dysphoric Disorder?

Premenstrual Dysphoric Disorder is a condition that occurs in women during their reproductive years about a week or two before menstruation. It is accompanied by many of the most common premenstrual symptoms (PMS) including breast tenderness, fatigue, bloating, and headaches, yet with the addition of more severe emotional and behavioral changes including:

  • Anger
  • Anxiety
  • Depression
  • Extreme sadness
  • Feelings of hopelessness
  • Irritability

Although these additional symptoms typically resolve themselves once menstruation starts, they can be so extreme that they become debilitating - even to the point of impacting work and personal relationships. In rare cases, PMDD can also lead to suicide in some individuals. Symptoms of Premenstrual Dysphoric Disorder can be so intense that PMDD has been listed (1) in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition as its own entity under Depressive disorders.

What causes PMDD?

While researchers are still uncovering the exact causes of Premenstrual Dysphoric Disorder, it is believed to be influenced by various factors including hormonal imbalances, specifically changes in estrogen and progesterone levels. Serotonin is also believed to play a role as this neurotransmitter plays a role in your mood and sleep and can fluctuate throughout your menstrual cycle.

How do I know if I have PMDD?

While there are no official lab tests to diagnose Premenstrual Dysphoric Disorder, as it is more or less based on an assessment of your symptoms. In general, to be diagnosed with PMDD your symptoms must line up with the following criteria.

  1. Your symptoms impact your ability to function with regular day-to-day activities, relationships, and work
  2. Your symptoms are not associated with another condition
  3. Your symptoms persist for at least a year alongside your menstrual cycles and  include 5 or more PMDD-specific symptoms.

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What are the risk factors for PMDD?

Certain women may be more prone to PMDD if they also have the following:

  • Anxiety
  • Depression
  • A family history of mood disorders, PMS, or PMDD
  • Past trauma

How do I treat PMDD?

In conventional medicine, PMDD is typically treated with medications to manage symptoms.

  • SSRI Antidepressants: Selective Serotonin Reuptake Inhibitors are a type of antidepressant often prescribed to help manage your brain’s serotonin levels that are believed to be low in cases of PMDD.
  • Hormonal birth control: These are one of the most commonly prescribed medications for rebalancing hormones like estrogen and progesterone.
  • Over-the-counter pain medicine: Ibuprofen and Tylenol are recommended to alleviate chronic pain related to cramps, breast tenderness, and headaches.

While these medications can be beneficial for some people in the short-term, they ultimately are nothing more than a bandaid for your symptoms. Functional medicine, on the other hand, approaches PMDD differently by addressing the underlying dysfunctions happening underneath the surface to alleviate symptoms for more long-term, sustainable relief.

How to treat PMDD naturally

Thankfully, there are many ways to naturally mitigate PMDD symptoms if you are looking to avoid medication.  While more research needs to be done specifically in relation to PMDD - not just PMS - these are the natural remedies that have been clinically-backed by research the most.

1. Target your supplements

As a functional medicine practitioner, I believe that food is foundational when it comes to getting everything you need to thrive. However, when you are dealing with a chronic condition like PMDD, research has shown that certain dosages of particular supplements can ease symptoms common with PMS and PMDD.

  • Calcium: Daily supplementation has been shown to reduce (2) both emotional and physical symptoms
  • Magnesium: Studies have found that magnesium can greatly improve symptoms with the greatest reduction (3) in symptoms happening as a result of taking magnesium and Vitamin B6 together.
  • Vitamin B6: Consistent supplementation has been shown to significantly improve PMS and PMDD symptoms, especially when taken alongside (4) calcium. In a recent study, (5) up to 60% of individuals completely alleviated their symptoms after just three cycles of taking Vitamin B6.

Instead of taking multiple different supplements, I personally formulated Protect with a blend of calcium glucarate and B vitamins to support your body’s natural ability to detox from hormone disrupting chemicals like xenoestrogens to help alleviate symptoms of PMS and PMDD.

2. Address any hormone imbalances

In functional medicine, the first step in overcoming hormone related health problems is by restoring any hormone imbalances. Considering PMDD is often correlated with imbalanced estrogen and progesterone levels, hormone labs will give you insight into whether or not these are a factor in your case of PMDD. If so, this information will give you and your doctor a clearer path toward the best way to address your symptoms.

3. Try herbal remedies

In addition to supplementing with micronutrients, herbal supplements have shown great promise for relieving PMDD symptoms - often without the side effects of commonly prescribed medications. 

Chaste tree berry, also known as vitex, is a tree that grows in the Mediterranean that has long been used for its health benefits, including aiding in symptoms associated (6) with PMDD and PMS. Another popular remedy for PMDD is St. John’s Wort. Research has found that supplementing with 900 mg per day provides (7) long-term relief from PMDD symptoms, making it a great alternative for those looking to treat their symptoms naturally or those who have experienced negative side effects from SSRIs. Just remember to talk with your doctor before taking these supplements if you are taking any sort of medication or are pregnant to avoid any potential reactions.

4. Take a warm bath

Not only can a warm bath offer relief from painful cramps and breast tenderness, it is also a great way to alleviate stress and anxiety that can be heighted in PMDD. You can pull double duty by adding in essential oils to your baths to take advantage of their vast aromatherapy benefits. Lavender essential oil in particular has even been shown (8) to decrease PMS-related emotional symptoms including depression.

The Takeaway

Whether you are diagnosed with PMDD officially or not, it is important to know that you are not alone when dealing with premenstrual symptoms. In functional medicine we take a comprehensive look at your health case to identify contributing factors to your condition in order to facilitate true, sustainable healing. Instead of living every month worrying about how you will feel, seek out the guidance of a functional medicine practitioner who can walk with you in alleviating your symptoms naturally.

If you are ready to take the next step in your hormonal healing journey, schedule a telehealth consultation today to learn more about how we can help you using functional medicine.

As one of the first functional medicine telehealth clinics in the world, we provide webcam health consultations for people around the globe.

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References:

  1. Mishra S, Elliott H, Marwaha R. Premenstrual Dysphoric Disorder. [Updated 2023 Feb 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532307/
  2. Arab, Arman et al. “Beneficial Role of Calcium in Premenstrual Syndrome: A Systematic Review of Current Literature.” International journal of preventive medicine vol. 11 156. 22 Sep. 2020, doi:10.4103/ijpvm.IJPVM_243_19
  3. Fathizadeh, Nahid et al. “Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome.” Iranian journal of nursing and midwifery research vol. 15,Suppl 1 (2010): 401-5.
  4. Masoumi, Seyedeh Zahra et al. “Effect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical Trial.” Journal of caring sciences vol. 5,1 67-73. 1 Mar. 2016, doi:10.15171/jcs.2016.007
  5. Retallick-Brown, Hāna et al. “A Pilot Randomized Treatment-Controlled Trial Comparing Vitamin B6 with Broad-Spectrum Micronutrients for Premenstrual Syndrome.” Journal of alternative and complementary medicine (New York, N.Y.) vol. 26,2 (2020): 88-97. doi:10.1089/acm.2019.0305
  6. Rafieian-Kopaei, Mahmoud, and Mino Movahedi. “Systematic Review of Premenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus.” Electronic physician vol. 9,1 3685-3689. 25 Jan. 2017, doi:10.19082/3685
  7. Huang, Kai-Lin, and Shih-Jen Tsai. “St. John's wort (Hypericum perforatum) as a treatment for premenstrual dysphoric disorder: case report.” International journal of psychiatry in medicine vol. 33,3 (2003): 295-7. doi:10.2190/RERY-N6AC-NADC-EHY4
  8. Matsumoto, Tamaki et al. “Does lavender aromatherapy alleviate premenstrual emotional symptoms?: a randomized crossover trial.” BioPsychoSocial medicine vol. 7 12. 31 May. 2013, doi:10.1186/1751-0759-7-12

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BY DR. WILL COLE

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Dr. Will Cole, DNM, IFMCP, DC is a leading functional medicine expert who consults people around the globe, starting one of the first functional medicine telehealth centers in the world. Named one of the top 50 functional and integrative doctors in the nation, Dr. Will Cole provides a functional medicine approach for thyroid issues, autoimmune conditions, hormonal imbalances, digestive disorders, and brain problems. He is also the host of the popular The Art of Being Well podcast and the New York Times bestselling author of Intuitive Fasting, Ketotarian, Gut Feelings, and The Inflammation Spectrum.

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