Methylsulfonylmethane, often abbreviated to MSMS, is not only a mouthful, but offers a truly impressive wealth of health benefits for a range of issues. Popularized many years ago as an anti-inflammatory supplement for osteoarthritis pain, its benefits have been proven in animal and human studies to reach far beyond joint pain.

What Is MSM (Methylsulfonylmethane)?

Methylsulfonylmethane (which can also go by dimethyl sulfone, methyl sulfone, sulfonylbismethane, organic sulfur, or crystalline dimethyl sulfoxide) was actually used first in the 50s as a commercial solvent. (1) It wasn’t until the 70s that the medical community began recognizing its unique and far reaching anti-inflammatory and antioxidative properties.

5 Evidence-Based Benefits of MSM Supplements

One could argue that a supplement that is anti-inflammatory and anti-oxidative has nearly endless potential benefits, the following are five areas with a lot of scientific evidence to back up its efficacy.

1. Treating joint pain and soreness

Studies have repeatedly shown MSM’s efficacy in reducing joint pain, especially pain associated with osteoarthritis. (2) It has also been shown to help reduce acute soreness associated with heavy exertion and exercise. (3) 

2. Promoting joint mobility 

Studies have also shown that in addition to reducing/preventing pain, MSM supplementation can actually help people improve their range of motion. As a combined effect, this with pain reduction can have life-changing effects on anyone struggling with disease or injury that affect mobility. And with daily movement being a key tenet of health, these combined outcomes can dramatically improve someone’s overall well-being and recovery outcomes.

3. Skin benefits

Pain-free and beautiful too? While less imperative to health than joint mobility and pain prevention, glowing, youthful skin is no small thing to many people. MSM has been shown in clinical studies to help improve pigmentation, skin elasticity, and reduce wrinkling. (3) This is not surprising given the impact we know antioxidants support skin health. MSM can be a great tool in your functional medicine beauty toolkit.

4. Allergies

Whether you’re in the thick of hay fever or cursing the dust in your own home, battling allergies can be incredibly frustrating. One study found MSM to be supportive in individual managing their allergy symptoms, though it’s important to note the study did find that MSM had an effect on histamine levels. (4)

5. Possible cancer prevention

Emerging science suggests that MSM may be a promising supplement in cancer prevention. Several in vitro studies have seen the compound’s ability to kill or prevent cancer cells. Though additional research is required to confirm this in real human subjects, it’s exciting to see new ways functional health staples applied in cancer prevention.(4)