Next Gen GLP-1, Peptides, Deep Plane Facelifts, Minimally Invasive Skin Treatments & The Tea on Housewives & Botched | Dr. Terry Dubrow

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I've watched Dr. Terry Dubrow on TV for years — Botched is, genuinely, a show my wife and I watch together as a love language — and sitting across from him in person, I was not disappointed.

Terry is operating at a kind of intellectual speed that makes for a great conversation partner: he moves from retatrutide to AI singularity theory to PFO anatomy to the chatbot platform where artificial intelligences talk to each other and collectively arrive at the conclusion that humans need to be controlled — all in the same breath, all with the same enthusiastic energy. He's 67, his mother is 92 with Alzheimer's, and he is in a state of active, intentional preservation. He calls the body a "meat body" — the temporary vessel for your consciousness and soul — and his philosophy is essentially this: you're renting it, and if you don't pay rent every day, you'll be evicted. He means that literally.

The story about signing Heather's name to the Real Housewives contract without her knowledge is worth the listen alone. She had said absolutely not, multiple times. He told the producers she was in. Played the long game for two weeks. She finally said yes — and then he revealed that the contract had already been signed. It is a very Terry move. And the rest is television history.

We also went deep on the state of peptides (retatrutide as the most exciting thing in the space, compounding pharmacies being legal again as essential for quality control), what minimally invasive skin treatments are actually worth doing (and the high-frequency approach that most people are getting wrong), the $1 million facelift patient who came to him still looking botched, and a prescription supplement stack that might raise some eyebrows — low-dose Cialis for vasodilation, baby aspirin, losartan, and a statin, all at doses below what's typically prescribed, all because he's managing his aging body like a precision instrument. And then there's the TIA he had at The Ivy in LA — slurred words for one minute at dinner — and the 30% of the population walking around with an undetected hole in their heart that most people never know about until it's too late.

A few of my favorite things we cover in this episode: 

• How Terry accidentally got Heather onto Real Housewives of Orange County — by literally signing her name to the contract without telling her
• The show that started it all: The Swan (Fox, 2003, 30 million viewers per episode) and the far more chaotic Bridal Plasty — and why neither could exist today
• Why the show was called Botched instead of its original name (which the advertisers killed one week before launch)
• Retatrutide (RTA): the triple agonist next-gen GLP-1 — GIP + GLP-1 + glucagon — that preserves muscle, burns fat, and shows preliminary data for slowing tumor growth
• Why compounding peptides being legal again matters: when they go off-market, they go full black market China with no sterile controls or endotoxin testing
• High-dose creatine experiment: Terry and Heather tested 15–20g/day on an Oura ring with neuropsychological memory tests — and sleep deprivation's cognitive impact was largely erased
• Terry's mother is 92 with Alzheimer's — why he, like Chris Hemsworth, refuses to test for the APOE4 gene and just focuses on minimizing expression
• AI in healthcare: the Singularity, recursive self-learning, physical AI in robots — and the chatbot platform where AIs talk to each other and collectively conclude humans should be controlled
• Why the price of intelligence is going to zero — and what jobs survive (builders, surgeons, physical tradespeople)
• The future of plastic surgery: why scalpels/scissors/sutures are still used 40 years later, and why radio frequency microneedling + new XREF device + fractionated CO2 are the current best minimally invasive options
• Why you should do non-invasive skin treatments on high frequency (6-8 sessions) rather than once and waiting — it's more like exercise than a one-time fix
• The $1 million facelift disaster: a patient who spent $350K with one surgeon and $560K with another in New York — and still came to Terry botched
• Terry's TIA at The Ivy restaurant: slurred words for one minute, ended up with a diagnosis of PFO (hole in the heart from birth), fixed in a 3-minute titanium plug procedure through the groin
• His "prescription supplement" stack: low-dose Cialis (for vasodilation, not ED), baby aspirin, low-dose losartan, low-dose rosuvastatin — microdosing pharmaceuticals for preservation
• "You're renting your meat body": the philosophy of treating daily health maintenance as a job — 7,500 steps, resistance training twice a week, move every day without exception
• Therapeutic plasma exchange: Terry's open to it in the right clinical setting, but the surgery-trained blood-outside-body concern is real
• LSD at 19, mushrooms, and why he hasn't touched anything stronger than a vodka soda in years — plus his take on the future of ketamine and psychedelic therapy

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Happy listening, and we hope you learned a little bit more on the art of being well!

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In Health,

Dr. Will Cole