Biohacking the Brain, Beating Genetic Risk, Ketone Myths & The Power of the 4th Macronutrient | Dr. Latt Mansor

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When it comes to metabolic health, Dr. Latt Mansor is rewriting the rulebook. In this episode, I sat down with the Oxford-trained researcher and former military consultant to explore everything from exogenous ketones to biohacking the brain. We talk about the rise of ketones as a fourth macronutrient, how they impact brain performance and recovery, and what his groundbreaking research with U.S. Special Ops revealed about fueling performance under extreme conditions. We also dig into his personal story - how he went from smoking 30 cigarettes a day to leading some of the world’s most innovative studies on metabolism. If you’ve ever wondered whether ketones are worth the hype, this episode delivers science-backed insight with zero fluff.

Dr. Latt Mansor holds a PhD in Physiology, Anatomy and Genetics from the University of Oxford, where his research focused on the metabolism of the type 2 diabetic heart in hypoxia. He also holds an M.A. (Columbia University) and B.Sc. (Hons) (University of Nottingham) in Biotechnology. He is a world expert in physiology and metabolism, and consults with elite sport, military, clinical and research organizations.

A few of my favorite things we cover in this episode: 

• Dr. Mansor’s personal health journey - from smoking and weight gain to biohacking and metabolic health
• How he went from Oxford PhD to leading a $6M military-backed study on ketones and altitude performance
• The science behind exogenous vs. endogenous ketones - and when to use them
• Ketones as the “fourth macronutrient” and their role in brain performance, recovery, and mental clarity
• How ketone esters can support hypoxia, longevity, and exercise performance
• The relationship between metabolic flexibility and chronic disease prevention
• What most people get wrong about low-carb diets and ketone supplementation
• His views on digital health, continuous tracking, and why data is key to empowerment
• The emotional and mental shifts that happen when you take control of your health

Links to things we talked about in this episode: 

• Save 30% off your first subscription order & receive a free six pack of Ketone-IQ with KETONE.com/WILLCOLE

Happy listening and we hope you learned a little bit more on the art of being well!

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In Health,

Dr. Will Cole